Animal viruses can be classified into DNA and RNA viruses (retroviruses). The department has active groups in both types of viruses. The two DNA viruses which are under active investigation are the herpes simplex virus I and polyoma virus. The regulation of gene expression in herpes simplex virus is under active investigation. The polyoma virus is being studied for its cell-specific replication. What parameters define the organ and tissue specificity?
This question is extremely important in understanding the infection of viruses in general. The gene therapy approach is being investigated for the central nervous system and evaluation is underway for an ex vivo model for human cervical cancer.
Retroviruses have been important models for studying gene expression and cancer. The molecular mechanisms involved in the development are significant research activities in the department. The virus that causes T cell leukemia is also under investigation.
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